Endophilin and synaptojanin hook up to promote synaptic vesicle endocytosis

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals. This remarkable pairing of two enzymatic activities promotes multiple steps of clathrin-mediated endocytosis of synaptic vesicles.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
Issue number4
StatePublished - Nov 13 2003

ASJC Scopus subject areas

  • Neuroscience(all)


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