TY - JOUR
T1 - Endometriosis and the risk of skin cancer
T2 - a prospective cohort study
AU - Farland, Leslie V.
AU - Lorrain, Simon
AU - Missmer, Stacey A.
AU - Dartois, Laureen
AU - Cervenka, Iris
AU - Savoye, Isabelle
AU - Mesrine, Sylvie
AU - Boutron-Ruault, Marie Christine
AU - Kvaskoff, Marina
N1 - Funding Information:
We are grateful to the study subjects for their continued participation; to Dr. Nicolas Chopin, Dr. Hervé Foulot, and Prof. Charles Chapron for reviewing endometriosis cases for the validation study; and to Dr. Jean Verdebout for providing data on mean daily ultraviolet radiation dose in French metropolitan departments. We also thank all members of the E3N-EPIC study group, particularly Marie Fangon, Pascale Gerbouin-Rérolle, Lyan Hoang, Céline Kernaleguen, Camille Laplanche, Maryvonne Niravong, and Maxime Valdenaire for their technical assistance, and we warmly thank Anne Bijon for her work on the E3N skin cancer database. The E3N cohort from the French National Institute of Health and Medical Research (Inserm) was supported by the Mutuelle Générale de l’Education Nationale (MGEN); the Gustave Roussy Institute; and the French League against Cancer (LNCC). MK was supported by a Marie Curie Fellowship within the 7th European Community Framework Programme (#PIOF-GA-2011-302078), and through the Young Researcher Prize from the Bettencourt-Schueller Foundation and the Jean Darier Prize delivered by the SVR Laboratories. LVF was supported by a T32 Grant (#HD060454) in reproductive, perinatal, and pediatric epidemiology from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Cancer Institute (3R25CA057711) National Institutes of Health.
Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Purpose: Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. Methods: E3N is a prospective cohort of 98,995 French women aged 40–65 years in 1990. Data on surgically confirmed endometriosis and skin cancer diagnoses were collected every 2–3 years through self-report, with skin cancer cases confirmed through pathology reports. Hazard Ratios (HR) and 95% confidence intervals (CIs) were calculated using Cox regression models. Results: Between 1990 and 2008, 535 melanoma, 247 squamous-cell carcinoma (SCC), and 1,712 basal-cell carcinoma (BCC) cases were ascertained. Endometriosis was associated with an increased overall risk of skin cancer (HR 1.28, 95% CI 1.05–1.55). When considering skin cancer type, endometriosis was associated with melanoma risk (HR 1.64, 95% CI 1.15–2.35), but not with SCC (HR 1.21, 95% CI 0.62–2.36) or BCC (HR 1.16, 95% CI 0.91–1.48) (non-melanoma skin cancers combined: HR 1.17, 95% CI 0.93–1.46), although no heterogeneity was detected across skin cancer types (Phomogeneity = 0.13). Conclusion: These data support an association between a personal history of endometriosis and the risk of skin cancer and suggest that the association is strongest for melanoma.
AB - Purpose: Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. Methods: E3N is a prospective cohort of 98,995 French women aged 40–65 years in 1990. Data on surgically confirmed endometriosis and skin cancer diagnoses were collected every 2–3 years through self-report, with skin cancer cases confirmed through pathology reports. Hazard Ratios (HR) and 95% confidence intervals (CIs) were calculated using Cox regression models. Results: Between 1990 and 2008, 535 melanoma, 247 squamous-cell carcinoma (SCC), and 1,712 basal-cell carcinoma (BCC) cases were ascertained. Endometriosis was associated with an increased overall risk of skin cancer (HR 1.28, 95% CI 1.05–1.55). When considering skin cancer type, endometriosis was associated with melanoma risk (HR 1.64, 95% CI 1.15–2.35), but not with SCC (HR 1.21, 95% CI 0.62–2.36) or BCC (HR 1.16, 95% CI 0.91–1.48) (non-melanoma skin cancers combined: HR 1.17, 95% CI 0.93–1.46), although no heterogeneity was detected across skin cancer types (Phomogeneity = 0.13). Conclusion: These data support an association between a personal history of endometriosis and the risk of skin cancer and suggest that the association is strongest for melanoma.
KW - Cohort studies
KW - Cutaneous melanoma
KW - Endometriosis
KW - Epidemiology
KW - Skin cancer
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U2 - 10.1007/s10552-017-0939-2
DO - 10.1007/s10552-017-0939-2
M3 - Article
C2 - 28799019
AN - SCOPUS:85027186318
VL - 28
SP - 1011
EP - 1019
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 10
ER -