Endogenous bioactive lipids and the regulation of conventional outflow facility

Zhou Wan, David F. Woodward, W. Daniel Stamer

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Perturbation of paracrine signaling within the human conventional outflow pathway influences tissue homeostasis and outflow function. For example, exogenous introduction of the bioactive lipids, sphingosine-1-phosphate, anandamide or prostaglandin F, to conventional outflow tissues alters the rate of drainage of aqueous humor through the trabecular meshwork and into Schlemm's canal. This review summarizes recent data that characterize endogenous bioactive lipids, their receptors and associated signaling partners in the conventional outflow tract. We also discuss the potential of targeting such signaling pathways as a strategy for the development of therapeutics to treat ocular hypertension and glaucoma.

Original languageEnglish (US)
Pages (from-to)457-470
Number of pages14
JournalExpert Review of Ophthalmology
Volume3
Issue number4
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Endocannabinoid
  • Glaucoma
  • Intraocular pressure
  • Lysophospholipid
  • Outflow facility
  • Prostaglandin
  • Prostamide
  • Schlemm's canal
  • Trabecular meshwork

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

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