Endogenous bioactive lipids and the regulation of conventional outflow facility

Zhou Wan, David F. Woodward, W. Daniel Stamer

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Perturbation of paracrine signaling within the human conventional outflow pathway influences tissue homeostasis and outflow function. For example, exogenous introduction of the bioactive lipids, sphingosine-1-phosphate, anandamide or prostaglandin F, to conventional outflow tissues alters the rate of drainage of aqueous humor through the trabecular meshwork and into Schlemm's canal. This review summarizes recent data that characterize endogenous bioactive lipids, their receptors and associated signaling partners in the conventional outflow tract. We also discuss the potential of targeting such signaling pathways as a strategy for the development of therapeutics to treat ocular hypertension and glaucoma.

Original languageEnglish (US)
Pages (from-to)457-470
Number of pages14
JournalExpert Review of Ophthalmology
Issue number4
StatePublished - Aug 2008


  • Endocannabinoid
  • Glaucoma
  • Intraocular pressure
  • Lysophospholipid
  • Outflow facility
  • Prostaglandin
  • Prostamide
  • Schlemm's canal
  • Trabecular meshwork

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry


Dive into the research topics of 'Endogenous bioactive lipids and the regulation of conventional outflow facility'. Together they form a unique fingerprint.

Cite this