Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction

Guangshun Luo, Shilei Zhang, Wenhu Duan, Wei Wang

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

A catalytic asymmetric Michael-aldol cascade process for efficient synthesis of trisubstituted tetrahydrothiophenes is reported with high enantio- and diastereo-selectivities. Notably, three consecutive stereogenic centers including one chiral quaternary carbon center are efficiently created in the 'one-pot' operation.

Original languageEnglish (US)
Pages (from-to)2946-2948
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number24
DOIs
StatePublished - Jun 17 2009
Externally publishedYes

Keywords

  • Cascade reactions
  • Michael-aldol
  • Organocatalysis
  • Tetrahydrothiophenes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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