Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

Xuyun Chen, Yang Yu, Ziyang Liao, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.

Original languageEnglish (US)
Pages (from-to)5742-5745
Number of pages4
JournalTetrahedron Letters
Volume57
Issue number51
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Benzyl chloride
  • Cinnamaldehyde
  • Diarylyclopropane
  • Enantioselective
  • Organocatalysis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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