Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

Xuyun Chen; Yang Yu; Ziyang Liao; Hao Li; Wei Wang

doi:10.1016/j.tetlet.2016.10.097

Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

Xuyun Chen, Yang Yu, Ziyang Liao, Hao Li, Wei Wang

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.

Original language	English (US)
Pages (from-to)	5742-5745
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	51
DOIs	https://doi.org/10.1016/j.tetlet.2016.10.097
State	Published - 2016
Externally published	Yes

Keywords

Benzyl chloride
Cinnamaldehyde
Diarylyclopropane
Enantioselective
Organocatalysis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2016.10.097

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title = "Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis",

abstract = "An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.",

keywords = "Benzyl chloride, Cinnamaldehyde, Diarylyclopropane, Enantioselective, Organocatalysis",

author = "Xuyun Chen and Yang Yu and Ziyang Liao and Hao Li and Wei Wang",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.tetlet.2016.10.097",

language = "English (US)",

volume = "57",

pages = "5742--5745",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

AU - Chen, Xuyun

AU - Yu, Yang

AU - Liao, Ziyang

AU - Li, Hao

AU - Wang, Wei

PY - 2016

Y1 - 2016

N2 - An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.

AB - An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.

KW - Benzyl chloride

KW - Cinnamaldehyde

KW - Diarylyclopropane

KW - Enantioselective

KW - Organocatalysis

UR - http://www.scopus.com/inward/record.url?scp=84997815950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84997815950&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2016.10.097

DO - 10.1016/j.tetlet.2016.10.097

M3 - Article

AN - SCOPUS:84997815950

SN - 0040-4039

VL - 57

SP - 5742

EP - 5745

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

Abstract

Keywords

ASJC Scopus subject areas

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