Enantioselective organocatalytic tandem Michael-Aldol reactions: One-pot synthesis of chiral thiochromenes

Wei Wang, Hao Li, Jian Wang, Liansuo Zu

Research output: Contribution to journalArticlepeer-review

384 Scopus citations

Abstract

A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.

Original languageEnglish (US)
Pages (from-to)10354-10355
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number32
DOIs
StatePublished - Aug 16 2006
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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