A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|State||Published - Aug 16 2006|
ASJC Scopus subject areas
- Colloid and Surface Chemistry