Enantioselective organocatalytic tandem Michael-Aldol reactions: One-pot synthesis of chiral thiochromenes

Wei Wang; Hao Li; Jian Wang; Liansuo Zu

doi:10.1021/ja063328m

Enantioselective organocatalytic tandem Michael-Aldol reactions: One-pot synthesis of chiral thiochromenes

Wei Wang, Hao Li, Jian Wang, Liansuo Zu

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.

Original language	English (US)
Pages (from-to)	10354-10355
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	32
DOIs	https://doi.org/10.1021/ja063328m
State	Published - Aug 16 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Enantioselective organocatalytic tandem Michael-Aldol reactions: One-pot synthesis of chiral thiochromenes",

abstract = "A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.",

author = "Wei Wang and Hao Li and Jian Wang and Liansuo Zu",

year = "2006",

month = aug,

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doi = "10.1021/ja063328m",

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T2 - One-pot synthesis of chiral thiochromenes

AU - Wang, Wei

AU - Li, Hao

AU - Wang, Jian

AU - Zu, Liansuo

PY - 2006/8/16

Y1 - 2006/8/16

N2 - A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.

AB - A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds.

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Enantioselective organocatalytic tandem Michael-Aldol reactions: One-pot synthesis of chiral thiochromenes

Abstract

ASJC Scopus subject areas

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