Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

Shanchao Wu; Yu Li; Yongqiang Zhang; Kun Fang; Guoqiang Dong; Na Liu; Zhenyuan Miao; Jianzhong Yao; Wei Wang; Wannian Zhang; Chunquan Sheng

doi:10.1039/c5ob02457a

Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

Shanchao Wu
, Yu Li
, Yongqiang Zhang
, Kun Fang
, Guoqiang Dong
, Na Liu
, Zhenyuan Miao
, Jianzhong Yao
, Wei Wang
, Wannian Zhang
, Chunquan Sheng

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.

Original language	English (US)
Pages (from-to)	3926-3933
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	16
DOIs	https://doi.org/10.1039/c5ob02457a
State	Published - Apr 28 2016
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c5ob02457a

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title = "Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes",

abstract = "The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.",

author = "Shanchao Wu and Yu Li and Yongqiang Zhang and Kun Fang and Guoqiang Dong and Na Liu and Zhenyuan Miao and Jianzhong Yao and Wei Wang and Wannian Zhang and Chunquan Sheng",

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TY - JOUR

T1 - Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

AU - Wu, Shanchao

AU - Li, Yu

AU - Zhang, Yongqiang

AU - Fang, Kun

AU - Dong, Guoqiang

AU - Liu, Na

AU - Miao, Zhenyuan

AU - Yao, Jianzhong

AU - Wang, Wei

AU - Zhang, Wannian

AU - Sheng, Chunquan

PY - 2016/4/28

Y1 - 2016/4/28

N2 - The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.

AB - The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.

UR - https://www.scopus.com/pages/publications/84970959736

UR - https://www.scopus.com/pages/publications/84970959736#tab=citedBy

U2 - 10.1039/c5ob02457a

DO - 10.1039/c5ob02457a

M3 - Article

AN - SCOPUS:84970959736

SN - 1477-0520

VL - 14

SP - 3926

EP - 3933

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 16

ER -

Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

Abstract

ASJC Scopus subject areas

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