Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

Shanchao Wu, Yu Li, Yongqiang Zhang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Wei Wang, Wannian Zhang, Chunquan Sheng

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.

Original languageEnglish (US)
Pages (from-to)3926-3933
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number16
DOIs
StatePublished - Apr 28 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes'. Together they form a unique fingerprint.

Cite this