Enantioselective organocatalytic double Michael addition reactions

Hao Li, Liansuo Zu, Hexin Xie, Jian Wang, Wei Jiang, Wei Wang

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2- butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.

Original languageEnglish (US)
Pages (from-to)1833-1835
Number of pages3
JournalOrganic Letters
Volume9
Issue number9
DOIs
StatePublished - Apr 26 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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