Enantioselective organocatalytic double Michael addition reactions

Hao Li; Liansuo Zu; Hexin Xie; Jian Wang; Wei Jiang; Wei Wang

doi:10.1021/ol070581y

Enantioselective organocatalytic double Michael addition reactions

Hao Li, Liansuo Zu, Hexin Xie, Jian Wang, Wei Jiang, Wei Wang

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2- butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.

Original language	English (US)
Pages (from-to)	1833-1835
Number of pages	3
Journal	Organic Letters
Volume	9
Issue number	9
DOIs	https://doi.org/10.1021/ol070581y
State	Published - Apr 26 2007
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol070581y

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title = "Enantioselective organocatalytic double Michael addition reactions",

abstract = "A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2- butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.",

author = "Hao Li and Liansuo Zu and Hexin Xie and Jian Wang and Wei Jiang and Wei Wang",

year = "2007",

month = apr,

day = "26",

doi = "10.1021/ol070581y",

language = "English (US)",

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journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Enantioselective organocatalytic double Michael addition reactions

AU - Li, Hao

AU - Zu, Liansuo

AU - Xie, Hexin

AU - Wang, Jian

AU - Jiang, Wei

AU - Wang, Wei

PY - 2007/4/26

Y1 - 2007/4/26

N2 - A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2- butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.

AB - A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2- butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.

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U2 - 10.1021/ol070581y

DO - 10.1021/ol070581y

M3 - Article

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SP - 1833

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JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Enantioselective organocatalytic double Michael addition reactions

Abstract

ASJC Scopus subject areas

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