Enantioselective Construction of Functionalized Cyclopentanes by a Relay Ring-Closing Metathesis and Chiral Amine (Thio)urea-Promoted Michael Addition

Yinan Zhang; Xixi Song; Xiaobei Chen; Aiguo Song; Shilei Zhang; Wei Wang

doi:10.1055/s-0034-1378321

Enantioselective Construction of Functionalized Cyclopentanes by a Relay Ring-Closing Metathesis and Chiral Amine (Thio)urea-Promoted Michael Addition

Yinan Zhang, Xixi Song, Xiaobei Chen, Aiguo Song, Shilei Zhang, Wei Wang

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A relay strategy is described that permits ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions to proceed in a one-pot fashion. The process offers an alternative approach to the synthesis of structurally diverse chiral cyclopentanes in good yields and good enantioselectivities.

Original language	English (US)
Pages (from-to)	2601-2607
Number of pages	7
Journal	Synthesis (Germany)
Volume	46
Issue number	19
DOIs	https://doi.org/10.1055/s-0034-1378321
State	Published - Oct 1 2014
Externally published	Yes

Keywords

Michael additions
cyclopentanes
metathesis
organocatalysis
organometallics
ring closure

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-0034-1378321

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abstract = "A relay strategy is described that permits ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions to proceed in a one-pot fashion. The process offers an alternative approach to the synthesis of structurally diverse chiral cyclopentanes in good yields and good enantioselectivities.",

keywords = "Michael additions, cyclopentanes, metathesis, organocatalysis, organometallics, ring closure",

author = "Yinan Zhang and Xixi Song and Xiaobei Chen and Aiguo Song and Shilei Zhang and Wei Wang",

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T1 - Enantioselective Construction of Functionalized Cyclopentanes by a Relay Ring-Closing Metathesis and Chiral Amine (Thio)urea-Promoted Michael Addition

AU - Zhang, Yinan

AU - Song, Xixi

AU - Chen, Xiaobei

AU - Song, Aiguo

AU - Zhang, Shilei

AU - Wang, Wei

PY - 2014/10/1

Y1 - 2014/10/1

N2 - A relay strategy is described that permits ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions to proceed in a one-pot fashion. The process offers an alternative approach to the synthesis of structurally diverse chiral cyclopentanes in good yields and good enantioselectivities.

AB - A relay strategy is described that permits ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions to proceed in a one-pot fashion. The process offers an alternative approach to the synthesis of structurally diverse chiral cyclopentanes in good yields and good enantioselectivities.

KW - Michael additions

KW - cyclopentanes

KW - metathesis

KW - organocatalysis

KW - organometallics

KW - ring closure

UR - https://www.scopus.com/pages/publications/84950327255

UR - https://www.scopus.com/inward/citedby.url?scp=84950327255&partnerID=8YFLogxK

U2 - 10.1055/s-0034-1378321

DO - 10.1055/s-0034-1378321

M3 - Article

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SN - 0039-7881

VL - 46

SP - 2601

EP - 2607

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 19

ER -

Enantioselective Construction of Functionalized Cyclopentanes by a Relay Ring-Closing Metathesis and Chiral Amine (Thio)urea-Promoted Michael Addition

Abstract

Keywords

ASJC Scopus subject areas

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