Enantioselective Construction of Functionalized Cyclopentanes by a Relay Ring-Closing Metathesis and Chiral Amine (Thio)urea-Promoted Michael Addition

Yinan Zhang, Xixi Song, Xiaobei Chen, Aiguo Song, Shilei Zhang, Wei Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A relay strategy is described that permits ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions to proceed in a one-pot fashion. The process offers an alternative approach to the synthesis of structurally diverse chiral cyclopentanes in good yields and good enantioselectivities.

Original languageEnglish (US)
Pages (from-to)2601-2607
Number of pages7
JournalSynthesis (Germany)
Volume46
Issue number19
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Keywords

  • Michael additions
  • cyclopentanes
  • metathesis
  • organocatalysis
  • organometallics
  • ring closure

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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