Emerging molecular diversity from the intra-molecular Ugi reaction: Iterative efficiency in medicinal chemistry

Christopher Hulme; Justin Dietrich

doi:10.1007/s11030-009-9111-6

Emerging molecular diversity from the intra-molecular Ugi reaction: Iterative efficiency in medicinal chemistry

Christopher Hulme, Justin Dietrich

Research output: Contribution to journal › Review article › peer-review

139 Scopus citations

Abstract

This review details a now established area within the isonitrile multi-component reaction (IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the construction of screening sets with the additional element or even possibly 'metric' of enhanced 'iterative efficiency potential'. The concept of 'iterative efficiency' will be briefly introduced, coupled with discussion on new synthetic routes to select bi-functional IMCR precursors and their use in the generation of pharmacologically relevant 'molecular diversity'.

Original language	English (US)
Pages (from-to)	195-207
Number of pages	13
Journal	Molecular Diversity
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/s11030-009-9111-6
State	Published - May 2009

Keywords

IMCR
Iterative efficiency
MCR
Ugi reaction

ASJC Scopus subject areas

Catalysis
Information Systems
Molecular Biology
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1007/s11030-009-9111-6

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abstract = "This review details a now established area within the isonitrile multi-component reaction (IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the construction of screening sets with the additional element or even possibly 'metric' of enhanced 'iterative efficiency potential'. The concept of 'iterative efficiency' will be briefly introduced, coupled with discussion on new synthetic routes to select bi-functional IMCR precursors and their use in the generation of pharmacologically relevant 'molecular diversity'.",

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Emerging molecular diversity from the intra-molecular Ugi reaction: Iterative efficiency in medicinal chemistry

Abstract

Keywords

ASJC Scopus subject areas

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