Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

Nicole L. Washington; Karthik Gangavarapu; Mark Zeller; Alexandre Bolze; Elizabeth T. Cirulli; Kelly M. Schiabor Barrett; Brendan B. Larsen; Catelyn Anderson; Simon White; Tyler Cassens; Sharoni Jacobs; Geraint Levan; Jason Nguyen; Jimmy M. Ramirez; Charlotte Rivera-Garcia; Efren Sandoval; Xueqing Wang; David Wong; Emily Spencer; Refugio Robles-Sikisaka; Ezra Kurzban; Laura D. Hughes; Xianding Deng; Candace Wang; Venice Servellita; Holly Valentine; Peter De Hoff; Phoebe Seaver; Shashank Sathe; Kimberly Gietzen; Brad Sickler; Jay Antico; Kelly Hoon; Jingtao Liu; Aaron Harding; Omid Bakhtar; Tracy Basler; Brett Austin; Duncan MacCannell; Magnus Isaksson; Phillip G. Febbo; David Becker; Marc Laurent; Eric McDonald; Gene W. Yeo; Rob Knight; Louise C. Laurent; Eileen de Feo; Michael Worobey; Charles Y. Chiu; Marc A. Suchard; James T. Lu; William Lee; Kristian G. Andersen

doi:10.1016/j.cell.2021.03.052

Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

Nicole L. Washington, Karthik Gangavarapu, Mark Zeller, Alexandre Bolze, Elizabeth T. Cirulli, Kelly M. Schiabor Barrett, Brendan B. Larsen, Catelyn Anderson, Simon White, Tyler Cassens, Sharoni Jacobs, Geraint Levan, Jason Nguyen, Jimmy M. Ramirez, Charlotte Rivera-Garcia, Efren Sandoval, Xueqing Wang, David Wong, Emily Spencer, Refugio Robles-SikisakaEzra Kurzban, Laura D. Hughes, Xianding Deng, Candace Wang, Venice Servellita, Holly Valentine, Peter De Hoff, Phoebe Seaver, Shashank Sathe, Kimberly Gietzen, Brad Sickler, Jay Antico, Kelly Hoon, Jingtao Liu, Aaron Harding, Omid Bakhtar, Tracy Basler, Brett Austin, Duncan MacCannell, Magnus Isaksson, Phillip G. Febbo, David Becker, Marc Laurent, Eric McDonald, Gene W. Yeo, Rob Knight, Louise C. Laurent, Eileen de Feo, Michael Worobey, Charles Y. Chiu, Marc A. Suchard, James T. Lu, William Lee, Kristian G. Andersen

Research output: Contribution to journal › Article › peer-review

182 Scopus citations

Abstract

The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in the United States (US), tracking it back to its early emergence. We found that, while the fraction of B.1.1.7 varied by state, the variant increased at a logistic rate with a roughly weekly doubling rate and an increased transmission of 40%–50%. We revealed several independent introductions of B.1.1.7 into the US as early as late November 2020, with community transmission spreading it to most states within months. We show that the US is on a similar trajectory as other countries where B.1.1.7 became dominant, requiring immediate and decisive action to minimize COVID-19 morbidity and mortality.

Original language	English (US)
Pages (from-to)	2587-2594.e7
Journal	Cell
Volume	184
Issue number	10
DOIs	https://doi.org/10.1016/j.cell.2021.03.052
State	Published - May 13 2021
Externally published	Yes

Keywords

501Y.V1
B.1.1.7
COVID-19
SARS-CoV-2
VOC-202012/01
genomic epidemiology
variant of concern

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2021.03.052

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Washington, N. L., Gangavarapu, K., Zeller, M., Bolze, A., Cirulli, E. T., Schiabor Barrett, K. M., Larsen, B. B., Anderson, C., White, S., Cassens, T., Jacobs, S., Levan, G., Nguyen, J., Ramirez, J. M., Rivera-Garcia, C., Sandoval, E., Wang, X., Wong, D., Spencer, E., ... Andersen, K. G. (2021). Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States. Cell, 184(10), 2587-2594.e7. https://doi.org/10.1016/j.cell.2021.03.052

Washington, NL, Gangavarapu, K, Zeller, M, Bolze, A, Cirulli, ET, Schiabor Barrett, KM, Larsen, BB, Anderson, C, White, S, Cassens, T, Jacobs, S, Levan, G, Nguyen, J, Ramirez, JM, Rivera-Garcia, C, Sandoval, E, Wang, X, Wong, D, Spencer, E, Robles-Sikisaka, R, Kurzban, E, Hughes, LD, Deng, X, Wang, C, Servellita, V, Valentine, H, De Hoff, P, Seaver, P, Sathe, S, Gietzen, K, Sickler, B, Antico, J, Hoon, K, Liu, J, Harding, A, Bakhtar, O, Basler, T, Austin, B, MacCannell, D, Isaksson, M, Febbo, PG, Becker, D, Laurent, M, McDonald, E, Yeo, GW, Knight, R, Laurent, LC, de Feo, E, Worobey, M, Chiu, CY, Suchard, MA, Lu, JT, Lee, W & Andersen, KG 2021, 'Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States', Cell, vol. 184, no. 10, pp. 2587-2594.e7. https://doi.org/10.1016/j.cell.2021.03.052

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title = "Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States",

abstract = "The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in the United States (US), tracking it back to its early emergence. We found that, while the fraction of B.1.1.7 varied by state, the variant increased at a logistic rate with a roughly weekly doubling rate and an increased transmission of 40%–50%. We revealed several independent introductions of B.1.1.7 into the US as early as late November 2020, with community transmission spreading it to most states within months. We show that the US is on a similar trajectory as other countries where B.1.1.7 became dominant, requiring immediate and decisive action to minimize COVID-19 morbidity and mortality.",

keywords = "501Y.V1, B.1.1.7, COVID-19, SARS-CoV-2, VOC-202012/01, genomic epidemiology, variant of concern",

author = "Washington, {Nicole L.} and Karthik Gangavarapu and Mark Zeller and Alexandre Bolze and Cirulli, {Elizabeth T.} and {Schiabor Barrett}, {Kelly M.} and Larsen, {Brendan B.} and Catelyn Anderson and Simon White and Tyler Cassens and Sharoni Jacobs and Geraint Levan and Jason Nguyen and Ramirez, {Jimmy M.} and Charlotte Rivera-Garcia and Efren Sandoval and Xueqing Wang and David Wong and Emily Spencer and Refugio Robles-Sikisaka and Ezra Kurzban and Hughes, {Laura D.} and Xianding Deng and Candace Wang and Venice Servellita and Holly Valentine and {De Hoff}, Peter and Phoebe Seaver and Shashank Sathe and Kimberly Gietzen and Brad Sickler and Jay Antico and Kelly Hoon and Jingtao Liu and Aaron Harding and Omid Bakhtar and Tracy Basler and Brett Austin and Duncan MacCannell and Magnus Isaksson and Febbo, {Phillip G.} and David Becker and Marc Laurent and Eric McDonald and Yeo, {Gene W.} and Rob Knight and Laurent, {Louise C.} and {de Feo}, Eileen and Michael Worobey and Chiu, {Charles Y.} and Suchard, {Marc A.} and Lu, {James T.} and William Lee and Andersen, {Kristian G.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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doi = "10.1016/j.cell.2021.03.052",

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AU - Washington, Nicole L.

AU - Gangavarapu, Karthik

AU - Zeller, Mark

AU - Bolze, Alexandre

AU - Cirulli, Elizabeth T.

AU - Schiabor Barrett, Kelly M.

AU - Larsen, Brendan B.

AU - Anderson, Catelyn

AU - White, Simon

AU - Cassens, Tyler

AU - Jacobs, Sharoni

AU - Levan, Geraint

AU - Nguyen, Jason

AU - Ramirez, Jimmy M.

AU - Rivera-Garcia, Charlotte

AU - Sandoval, Efren

AU - Wang, Xueqing

AU - Wong, David

AU - Spencer, Emily

AU - Robles-Sikisaka, Refugio

AU - Kurzban, Ezra

AU - Hughes, Laura D.

AU - Deng, Xianding

AU - Wang, Candace

AU - Servellita, Venice

AU - Valentine, Holly

AU - De Hoff, Peter

AU - Seaver, Phoebe

AU - Sathe, Shashank

AU - Gietzen, Kimberly

AU - Sickler, Brad

AU - Antico, Jay

AU - Hoon, Kelly

AU - Liu, Jingtao

AU - Harding, Aaron

AU - Bakhtar, Omid

AU - Basler, Tracy

AU - Austin, Brett

AU - MacCannell, Duncan

AU - Isaksson, Magnus

AU - Febbo, Phillip G.

AU - Becker, David

AU - Laurent, Marc

AU - McDonald, Eric

AU - Yeo, Gene W.

AU - Knight, Rob

AU - Laurent, Louise C.

AU - de Feo, Eileen

AU - Worobey, Michael

AU - Chiu, Charles Y.

AU - Suchard, Marc A.

AU - Lu, James T.

AU - Lee, William

AU - Andersen, Kristian G.

PY - 2021/5/13

Y1 - 2021/5/13

N2 - The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in the United States (US), tracking it back to its early emergence. We found that, while the fraction of B.1.1.7 varied by state, the variant increased at a logistic rate with a roughly weekly doubling rate and an increased transmission of 40%–50%. We revealed several independent introductions of B.1.1.7 into the US as early as late November 2020, with community transmission spreading it to most states within months. We show that the US is on a similar trajectory as other countries where B.1.1.7 became dominant, requiring immediate and decisive action to minimize COVID-19 morbidity and mortality.

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KW - SARS-CoV-2

KW - VOC-202012/01

KW - genomic epidemiology

KW - variant of concern

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JO - Cell

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ER -

Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

Abstract

Keywords

ASJC Scopus subject areas

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