We evaluated the minimal molecular and cellular requirements for elicitation of anti-vesicular stomatitis virus (VSV) cytotoxic T lymphocytes (CTL). The results indicated that lipid vesicles containing the purified major surface glycoprotein of VSV (G protein) and purified H-2K(k) glycoproteins elicited specific H-2K(k)-restricted anti-VSV CTL. These antiviral CTL were shown to be Ly 1-, 2+. However, both Ly 1+, 2- and Ly1-, 2+ T-cell subpopulations were shown to be required for elicitation of these CTL.
ASJC Scopus subject areas
- Infectious Diseases