TY - JOUR
T1 - Electrophysiological abnormalities as indicators of early-stage pathology in Primary Progressive Aphasia (PPA)
T2 - A case study in semantic variant PPA
AU - Kielar, Aneta
AU - Shah-Basak, Priyanka P.
AU - Patterson, Dianne K.
AU - Jokel, Regina
AU - Meltzer, Jed A.
N1 - Funding Information:
This work was supported by a Basic Science Grant from the OntarioBrain Institute Ontario Neurodegenerative Disease Research Initiative(ONDRI), Canada to JAM, and Alzheimer's Association NewInvestigator Research Grant (NIRG-12-236224), Canada to JAM, and apostdoctoral research award from the Ontario Research Coalition,Canada to AK. We thank the participating volunteers and their families.
Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Language induced and spontaneous oscillatory activity was measured using MEG in a patient with the semantic variant of Primary Progressive Aphasia (svPPA) and 15 healthy controls.The patient showed oscillatory slowing in the left anterior temporal lobe (ATL) that extended into non-atrophied brain tissue in left and right frontal areas. The white matter connections were reduced to the left and right ATL and left frontal regions, exhibiting electrophysiological abnormalities. Altered diffusion metrics in all four language tracts, indicted compromised white matter integrity. Task-related and spontaneous oscillatory abnormalities can indicate early neurodegeneration in svPPA, providing promising targets for intervention.
AB - Language induced and spontaneous oscillatory activity was measured using MEG in a patient with the semantic variant of Primary Progressive Aphasia (svPPA) and 15 healthy controls.The patient showed oscillatory slowing in the left anterior temporal lobe (ATL) that extended into non-atrophied brain tissue in left and right frontal areas. The white matter connections were reduced to the left and right ATL and left frontal regions, exhibiting electrophysiological abnormalities. Altered diffusion metrics in all four language tracts, indicted compromised white matter integrity. Task-related and spontaneous oscillatory abnormalities can indicate early neurodegeneration in svPPA, providing promising targets for intervention.
KW - MEG
KW - Semantic PPA
KW - resting state oscillations
KW - sentence comprehension
KW - slowing
UR - https://www.scopus.com/pages/publications/85125951681
UR - https://www.scopus.com/pages/publications/85125951681#tab=citedBy
U2 - 10.1080/13554794.2022.2039207
DO - 10.1080/13554794.2022.2039207
M3 - Article
C2 - 35230912
AN - SCOPUS:85125951681
SN - 1355-4794
VL - 28
SP - 110
EP - 122
JO - Neurocase
JF - Neurocase
IS - 1
ER -