@article{443700dab5b54883984d9409eb4c6344,
title = "Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity",
abstract = "The mechanism of amiodarone-induced pulmonary toxicity is unknown. Two cases of amiodarone pulmonary toxicity are presented in which abnormal inclusion bodies containing whorls of membrane were seen on electron microscopy of extrapulmonary tissues. These cytoplasmic lysosomal inclusion bodies were observed in lymphocytes, plasma cells, granulocytes, tissue macrophages, and hepatocytes. These widespread histopathologic changes in extrapulmonary tissues and in a variety of cell types are similar to more extensively investigated findings in animal models that are thought to represent a drug-induced lysosomal storage disease, phospholipidosis.",
author = "Dake, {Michael D.} and Madison, {J. Mark} and Montgomery, {Carolyn K.} and Shellito, {Judd E.} and Hinchcliffe, {Warren A.} and Winkler, {Mark L.} and Bainton, {Dorothy F.}",
note = "Funding Information: From tha Depa&nenta of Medicine, Radiilogy, and Pathology, Veterans Administration Medical Center, the Cardiovascular Research Institute, and the Department of Pathology, University of California School of Medicine, San Francisco, California. This work was supported in part by a National Institutes of Health Institutional, National Research Service Award, HL-07185, to Dr. Madison, and National Institutes of Health Grant AM-10488 to Dr. Baintcn. Requests for reprints should be addressed to Dr. Dorothy F. Sainton, Dapart-ment of Pathology, University of California School of Medicine, San Francisco, California 94143. Manuscript accepted April 20, 1984.",
year = "1985",
month = mar,
doi = "10.1016/0002-9343(85)90346-8",
language = "English (US)",
volume = "78",
pages = "506--512",
journal = "The American journal of medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "3",
}