Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

Wei Yang; Liliang Huang; Hong Liu; Wei Wang; Hao Li

doi:10.1039/c3cc42216j

Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF₃)₂-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

Wei Yang
, Liliang Huang
, Hong Liu
, Wei Wang
, Hao Li

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We describe an unprecedented Pd(OCOCF₃)₂-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5-tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in “one-pot”.

Original language	English (US)
Pages (from-to)	4667-4669
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	41
DOIs	https://doi.org/10.1039/c3cc42216j
State	Published - Apr 30 2013
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc42216j

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abstract = "We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5-tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in “one-pot”.",

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AU - Huang, Liliang

AU - Liu, Hong

AU - Wang, Wei

AU - Li, Hao

PY - 2013/4/30

Y1 - 2013/4/30

N2 - We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5-tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in “one-pot”.

AB - We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5-tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in “one-pot”.

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Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF₃)₂-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

Abstract

ASJC Scopus subject areas

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