Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

Wei Yang, Liliang Huang, Hong Liu, Wei Wang, Hao Li

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5-tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in “one-pot”.

Original languageEnglish (US)
Pages (from-to)4667-4669
Number of pages3
JournalChemical Communications
Volume49
Issue number41
DOIs
StatePublished - Apr 30 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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