Efficient access to 2,3-diarylimidazo[1,2-a ]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation

Yuanxiang Wang; Brendan Frett; Hong Yu Li

doi:10.1021/ol501136e

Efficient access to 2,3-diarylimidazo[1,2-a ]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation

Yuanxiang Wang, Brendan Frett, Hong Yu Li

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

An expeditious one-pot, ligand-free, Pd(OAc)₂-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines analogues.

Original language	English (US)
Pages (from-to)	3016-3019
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	11
DOIs	https://doi.org/10.1021/ol501136e
State	Published - Jun 6 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "An expeditious one-pot, ligand-free, Pd(OAc)2-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines analogues.",

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Efficient access to 2,3-diarylimidazo[1,2-a ]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation

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