Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models

Edmund K. LeGrand, Kathleen E. Rodgers, Wefki Girgis, Karen Struck, Joseph D. Campeau, Gere S. diZerega, Timothy C. Kiorpes

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Tolmetin sodium’s efficacy in preventing primary adhesions was evaluated in two adhesion models each in two species: (1) rabbit uterine horn, (2) rat uterine horn, (3) rabbit peritoneal side wall, and (4) rat peritoneal side wall. In each model a single instillation of tolmetin sodium solution into the peritoneal cavity at the time of surgery effectively reduced adhesion formation. This efficacy extended over a wide range of concentrations, volumes, and total dosages, and was similar in rabbits and rats. An aqueous solution of 1 mg/ml tolmetin sodium in 5-15 ml in rabbits and in 3 ml in rats was consistently efficacious in reducing postoperative adhesion formation.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalJournal of Surgical Research
Volume56
Issue number1
DOIs
StatePublished - Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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