TY - JOUR
T1 - Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models
AU - LeGrand, Edmund K.
AU - Rodgers, Kathleen E.
AU - Girgis, Wefki
AU - Struck, Karen
AU - Campeau, Joseph D.
AU - diZerega, Gere S.
AU - Kiorpes, Timothy C.
PY - 1994/1
Y1 - 1994/1
N2 - Tolmetin sodium’s efficacy in preventing primary adhesions was evaluated in two adhesion models each in two species: (1) rabbit uterine horn, (2) rat uterine horn, (3) rabbit peritoneal side wall, and (4) rat peritoneal side wall. In each model a single instillation of tolmetin sodium solution into the peritoneal cavity at the time of surgery effectively reduced adhesion formation. This efficacy extended over a wide range of concentrations, volumes, and total dosages, and was similar in rabbits and rats. An aqueous solution of 1 mg/ml tolmetin sodium in 5-15 ml in rabbits and in 3 ml in rats was consistently efficacious in reducing postoperative adhesion formation.
AB - Tolmetin sodium’s efficacy in preventing primary adhesions was evaluated in two adhesion models each in two species: (1) rabbit uterine horn, (2) rat uterine horn, (3) rabbit peritoneal side wall, and (4) rat peritoneal side wall. In each model a single instillation of tolmetin sodium solution into the peritoneal cavity at the time of surgery effectively reduced adhesion formation. This efficacy extended over a wide range of concentrations, volumes, and total dosages, and was similar in rabbits and rats. An aqueous solution of 1 mg/ml tolmetin sodium in 5-15 ml in rabbits and in 3 ml in rats was consistently efficacious in reducing postoperative adhesion formation.
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U2 - 10.1006/jsre.1994.1011
DO - 10.1006/jsre.1994.1011
M3 - Article
C2 - 8277771
AN - SCOPUS:0027976365
VL - 56
SP - 67
EP - 71
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 1
ER -