Efficacy of ambruticin analogs in a murine model of coccidioidomycosis

Lisa F. Shubitz; John N. Galgiani; Zong Qiang Tian; Ziyang Zhong; Pieter Timmermans; Leonard Katz

doi:10.1128/AAC.00670-06

Efficacy of ambruticin analogs in a murine model of coccidioidomycosis

Lisa F. Shubitz
, John N. Galgiani
, Zong Qiang Tian
, Ziyang Zhong
, Pieter Timmermans
, Leonard Katz

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

Original language	English (US)
Pages (from-to)	3467-3469
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00670-06
State	Published - Oct 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Efficacy of ambruticin analogs in a murine model of coccidioidomycosis",

abstract = "Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.",

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AU - Tian, Zong Qiang

AU - Zhong, Ziyang

AU - Timmermans, Pieter

AU - Katz, Leonard

PY - 2006/10

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AB - Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

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AN - SCOPUS:33749519061

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ER -

Efficacy of ambruticin analogs in a murine model of coccidioidomycosis

Abstract

ASJC Scopus subject areas

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