TY - JOUR
T1 - Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors
T2 - A Prospective, Randomized, Controlled Trial
AU - Chen, Yingxin
AU - Liao, Congling
AU - Gao, Minghong
AU - Belin, Michael Wellington
AU - Wang, Mingwu
AU - Yu, Hai
AU - Yu, Jing
N1 - Publisher Copyright:
© 2015 Yingxin Chen et al.
PY - 2015
Y1 - 2015
N2 - Purpose. To assess the efficacy and safety of corneal transplantation using corneas from foreign donors. Methods. One hundred and eight patients needing therapeutic penetrating keratoplasty were randomly divided into 2 groups (54 cases/group): foreign group using foreign donor corneas and domestic group using domestic donor corneas. Clinical outcome and incidence of postoperative complications were compared between groups. Results. No significant difference with respect to the therapeutic outcome and postoperative Best Corrected Visual Acuity (BCVA) and neovascularization by final follow-up was observed between the two groups. The graft thickness in the foreign group was statistically higher than the domestic group at 1 month postoperatively, but not at 3, 6, and 12 months postoperatively. Corneal endothelial cell density in the domestic group was statistically higher than in the foreign group at 3, 6, and 12 months postoperatively. Corneal epithelial abnormalities in the foreign group were significantly higher than that in domestic group. The primary graft failure, incidence of graft survival, and postoperative complications such as immunologic rejection, graft infection, and secondary glaucoma were not significantly different between the two groups. Conclusions. Corneal transplantations using foreign donor corneas are as effective and safe as those using domestic donor corneas.
AB - Purpose. To assess the efficacy and safety of corneal transplantation using corneas from foreign donors. Methods. One hundred and eight patients needing therapeutic penetrating keratoplasty were randomly divided into 2 groups (54 cases/group): foreign group using foreign donor corneas and domestic group using domestic donor corneas. Clinical outcome and incidence of postoperative complications were compared between groups. Results. No significant difference with respect to the therapeutic outcome and postoperative Best Corrected Visual Acuity (BCVA) and neovascularization by final follow-up was observed between the two groups. The graft thickness in the foreign group was statistically higher than the domestic group at 1 month postoperatively, but not at 3, 6, and 12 months postoperatively. Corneal endothelial cell density in the domestic group was statistically higher than in the foreign group at 3, 6, and 12 months postoperatively. Corneal epithelial abnormalities in the foreign group were significantly higher than that in domestic group. The primary graft failure, incidence of graft survival, and postoperative complications such as immunologic rejection, graft infection, and secondary glaucoma were not significantly different between the two groups. Conclusions. Corneal transplantations using foreign donor corneas are as effective and safe as those using domestic donor corneas.
UR - http://www.scopus.com/inward/record.url?scp=84937137509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937137509&partnerID=8YFLogxK
U2 - 10.1155/2015/178289
DO - 10.1155/2015/178289
M3 - Article
AN - SCOPUS:84937137509
SN - 2090-004X
VL - 2015
JO - Journal of Ophthalmology
JF - Journal of Ophthalmology
M1 - 178289
ER -