Effects of subchronic treatment with O,O,S-trimethyl phosphorothioate on cellular and humoral immune response systems

K. E. Rodgers, T. Imamura, B. H. Devens

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effect of a 14-day treatment with low doses of O,O,S-Trimethyl phosphorothioate (OOS-TMP), an impurity in technical malathion, on the generation of cell-mediated and humoral immune responses was examined in female C57B1/6 mice. At a dose of 0.5 mg/kg/day OOS-TMP, the generation of antibody-secreting cells to sheep red blood cells (SRBC), the production of interleukin 2 (IL-2), and proliferative responses to the mitogens concanavalin A (Con A) and lipopolysaccharide (LPS) were elevated. In contrast, the cytotoxic T-lymphocyte (CTL) response to alloantigen was unchanged. At 5.0 mg/kg/day OOS-TMP, both the CTL and specific antibody response were unchanged, but all other immune parameters examined were elevated. Data from cell separation and reconstitution experiments indicated that both macrophages and B cells were affected by this treatment regime. These data suggest that long-term exposure to low amounts of OOS-TMP may enhance the ability of an animal to generate an immune response.

Original languageEnglish (US)
Pages (from-to)310-318
Number of pages9
JournalToxicology and Applied Pharmacology
Volume81
Issue number2
DOIs
StatePublished - Nov 1985
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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