TY - JOUR
T1 - Effects of subacute administration of O,S,S-trimethyl phosphorodithioate on cellular and humoral immune response systems
AU - Rodgers, K. E.
AU - Stern, M. L.
AU - Ware, C. F.
N1 - Funding Information:
*This work was supported in part by PHS Grant numbers ES03105 and ES04337. **To whom all correspondence and reprint requests should be addressed.
PY - 1989/2
Y1 - 1989/2
N2 - The effects of 14-day treatment with low doses of O,S,S-trimethyl phosphorodithionate (OSS-TMP), an impurity in technical malathion, on the generation of cell-mediated and humoral immune responses were examined in female C57BL/6 mice. At a dose of 2.0 mg/kg per day OSS-TMP, the generation of antibody-sectreting cells to sheep red blood cells, the generation of cytotoxic T lymphocytes (CTL) to alloantigen and the production of Interleukin-2 were elevated approximately 2-3 fold, while no changes were observed in the proliferative responses to the polyclonal activators, Concanavalin A, lipopolysaccharide, or phytohemagglutinin. In contrast, at 5.0 mg/kg per day OSS-TMP, both the CTL and specific antibody responses were suppressed, while all other immune parameters examined were unchanged. Data from cell separation and reconstitution experiments indicated that both T and B lymphocytes were affected by these treatment regimes. These data suggest that long-term exposure to low doses of OSS-TMP may enhance the ability of an animal to generate an immune response while higher doses of OSS-TMP may suppress the generation of an immune response.
AB - The effects of 14-day treatment with low doses of O,S,S-trimethyl phosphorodithionate (OSS-TMP), an impurity in technical malathion, on the generation of cell-mediated and humoral immune responses were examined in female C57BL/6 mice. At a dose of 2.0 mg/kg per day OSS-TMP, the generation of antibody-sectreting cells to sheep red blood cells, the generation of cytotoxic T lymphocytes (CTL) to alloantigen and the production of Interleukin-2 were elevated approximately 2-3 fold, while no changes were observed in the proliferative responses to the polyclonal activators, Concanavalin A, lipopolysaccharide, or phytohemagglutinin. In contrast, at 5.0 mg/kg per day OSS-TMP, both the CTL and specific antibody responses were suppressed, while all other immune parameters examined were unchanged. Data from cell separation and reconstitution experiments indicated that both T and B lymphocytes were affected by these treatment regimes. These data suggest that long-term exposure to low doses of OSS-TMP may enhance the ability of an animal to generate an immune response while higher doses of OSS-TMP may suppress the generation of an immune response.
KW - Allogeneic cellular immune response
KW - Humoral immune response
KW - O,S,S-Trimethyl phosphorodithiorate
KW - Subacute
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U2 - 10.1016/0300-483X(89)90044-9
DO - 10.1016/0300-483X(89)90044-9
M3 - Article
C2 - 2784238
AN - SCOPUS:0024564562
SN - 0300-483X
VL - 54
SP - 183
EP - 195
JO - Toxicology
JF - Toxicology
IS - 2
ER -