Effects of subacute administration of O,S,S-trimethyl phosphorodithioate on cellular and humoral immune response systems

K. E. Rodgers, M. L. Stern, C. F. Ware

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The effects of 14-day treatment with low doses of O,S,S-trimethyl phosphorodithionate (OSS-TMP), an impurity in technical malathion, on the generation of cell-mediated and humoral immune responses were examined in female C57BL/6 mice. At a dose of 2.0 mg/kg per day OSS-TMP, the generation of antibody-sectreting cells to sheep red blood cells, the generation of cytotoxic T lymphocytes (CTL) to alloantigen and the production of Interleukin-2 were elevated approximately 2-3 fold, while no changes were observed in the proliferative responses to the polyclonal activators, Concanavalin A, lipopolysaccharide, or phytohemagglutinin. In contrast, at 5.0 mg/kg per day OSS-TMP, both the CTL and specific antibody responses were suppressed, while all other immune parameters examined were unchanged. Data from cell separation and reconstitution experiments indicated that both T and B lymphocytes were affected by these treatment regimes. These data suggest that long-term exposure to low doses of OSS-TMP may enhance the ability of an animal to generate an immune response while higher doses of OSS-TMP may suppress the generation of an immune response.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalToxicology
Volume54
Issue number2
DOIs
StatePublished - Feb 1989
Externally publishedYes

Keywords

  • Allogeneic cellular immune response
  • Humoral immune response
  • O,S,S-Trimethyl phosphorodithiorate
  • Subacute

ASJC Scopus subject areas

  • Toxicology

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