Effects of Single Large Doses of Phenytoin on Glucose Homeostasis—a Preliminary Report

WILLIAM BANNER; DAVID G. JOHNSON; PHILIP D. WALSON; DONALD JUNG

doi:10.1002/j.1552-4604.1982.tb02652.x

Effects of Single Large Doses of Phenytoin on Glucose Homeostasis—a Preliminary Report

WILLIAM BANNER, DAVID G. JOHNSON, PHILIP D. WALSON, DONALD JUNG

Research output: Contribution to journal › Article › peer-review

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Abstract

Abstract: The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures. 1982 American College of Clinical Pharmacology

Original language	English (US)
Pages (from-to)	79-81
Number of pages	3
Journal	The Journal of Clinical Pharmacology
Volume	22
Issue number	2-3
DOIs	https://doi.org/10.1002/j.1552-4604.1982.tb02652.x
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1002/j.1552-4604.1982.tb02652.x

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abstract = "Abstract: The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures. 1982 American College of Clinical Pharmacology",

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AU - BANNER, WILLIAM

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AU - JUNG, DONALD

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AB - Abstract: The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures. 1982 American College of Clinical Pharmacology

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Effects of Single Large Doses of Phenytoin on Glucose Homeostasis—a Preliminary Report

Abstract

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