Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

Michelle Lee; Andrea Kim; Irene M. Conwell; Victor Hruby; Alexander Mayorov; Minying Cai; Sharon L. Wardlaw

doi:10.1016/j.peptides.2007.11.005

Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

Michelle Lee, Andrea Kim, Irene M. Conwell, Victor Hruby, Alexander Mayorov, Minying Cai, Sharon L. Wardlaw

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [d-Trp⁸]-γ-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake.

Original language	English (US)
Pages (from-to)	440-447
Number of pages	8
Journal	Peptides
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.peptides.2007.11.005
State	Published - Mar 2008

Keywords

Feeding
MSH
Melanocortin-3-receptor
POMC

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2007.11.005

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title = "Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression",

abstract = "Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [d-Trp8]-γ-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake.",

keywords = "Feeding, MSH, Melanocortin-3-receptor, POMC",

author = "Michelle Lee and Andrea Kim and Conwell, {Irene M.} and Victor Hruby and Alexander Mayorov and Minying Cai and Wardlaw, {Sharon L.}",

note = "Funding Information: This work was supported by NIH Grants DK57561, MH55708 (SLW) and DK17420 (VJH).",

year = "2008",

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doi = "10.1016/j.peptides.2007.11.005",

language = "English (US)",

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pages = "440--447",

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T1 - Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

AU - Lee, Michelle

AU - Kim, Andrea

AU - Conwell, Irene M.

AU - Hruby, Victor

AU - Mayorov, Alexander

AU - Cai, Minying

AU - Wardlaw, Sharon L.

N1 - Funding Information: This work was supported by NIH Grants DK57561, MH55708 (SLW) and DK17420 (VJH).

PY - 2008/3

Y1 - 2008/3

N2 - Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [d-Trp8]-γ-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake.

AB - Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [d-Trp8]-γ-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake.

KW - Feeding

KW - MSH

KW - Melanocortin-3-receptor

KW - POMC

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ER -

Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

Abstract

Keywords

ASJC Scopus subject areas

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