Effects of secretin on guanyl cyclase of various tissues

W. J. Thompson; D. G. Johnson; V. R. Lavis; R. H. Williams

doi:10.1210/endo-94-1-276

Effects of secretin on guanyl cyclase of various tissues

W. J. Thompson, D. G. Johnson, V. R. Lavis, R. H. Williams

Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Secretin (4 μg/ml) activated guanyl cyclase in 30, 000 × g supernatant preparations from rat liver, lung, skeletal muscle, pancreas, stomach, brain cortex, fat cells, isolated pancreatic islets and one human islet cell carcinoma, but not in supernatants from rat heart, small intestine and two other human islet cell carcinomas. Both islet cell carcinomas displayed high basal activities. Guanyl cyclase of the rat iris was inhibited by secretin. These studies suggest that guanyl cyclase has receptors for secretin in “nontarget” as well as “target” tissues.

Original language	English (US)
Pages (from-to)	276-278
Number of pages	3
Journal	Endocrinology
Volume	94
Issue number	1
DOIs	https://doi.org/10.1210/endo-94-1-276
State	Published - Jan 1974

ASJC Scopus subject areas

Endocrinology

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Effects of secretin on guanyl cyclase of various tissues

Abstract

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