Effects of physicochemical properties of nanomaterials on their toxicity

Xiaoming Li, Wei Liu, Lianwen Sun, Katerina E. Aifantis, Bo Yu, Yubo Fan, Qingling Feng, Fuzhai Cui, Fumio Watari

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Abstract Due to their unique size and properties, nanomaterials have numerous applications, which range from electronics, cosmetics, household appliances, energy storage, and semiconductor devices, to medical products such as biological sensors, drug carriers, bioprobes, and implants. Many of the promising properties of nanomaterials arise from their large surface to volume ratio and, therefore, nanobiomaterials that are implantable have a large contact area with the human body. Before, therefore, we can fully exploit nanomaterials, in medicine and bioengineering; it is necessary to understand how they can affect the human body. As a step in this direction, this review paper provides a comprehensive summary of the effects that the physicochemical properties of commonly used nanobiomaterials have on their toxicity. Furthermore, the possible mechanisms of toxicity are described with the aim to provide guidance concerning the design of the nanobiomaterials with desirable properties.

Original languageEnglish (US)
Pages (from-to)2499-2507
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Issue number7
StatePublished - Jul 1 2015


  • nanomaterials
  • nanoparticles
  • physicochemical properties
  • toxicity

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys


Dive into the research topics of 'Effects of physicochemical properties of nanomaterials on their toxicity'. Together they form a unique fingerprint.

Cite this