Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: An extracellular in vitro study

Ting Wang; Edward D. French

doi:10.1016/0024-3205(93)90610-F

Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: An extracellular in vitro study

Ting Wang, Edward D. French

Pharmacology

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Abstract

Extracellular single-unit recordings in rat midbrain slices were used to assess the effects of phencyclidine (PCP) on the spontaneous and excitatory amino acid-induced firing of ventral tegmental (VTA) dopamine neurons. Perfusion with PCP concentrations from 10 nM to 100 μM resulted in only minimal decreases in firing rate. Neither excitatory effects nor changes in firing pattern were ever observed upon exposure to PCP. In contrast, PCP selectively antagonized the stimulatory effects of N-methyl-D-aspartate (NMDA), but did not alter α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)- or kainate (KA)-induced excitations. These results are discussed in relation to the low-dose stimulatory effects of PCP on ventral tegmental A10 dopamine neurons in the whole animal preparation.

Original language	English (US)
Pages (from-to)	49-56
Number of pages	8
Journal	Life Sciences
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/0024-3205(93)90610-F
State	Published - 1993

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(93)90610-F

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title = "Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: An extracellular in vitro study",

abstract = "Extracellular single-unit recordings in rat midbrain slices were used to assess the effects of phencyclidine (PCP) on the spontaneous and excitatory amino acid-induced firing of ventral tegmental (VTA) dopamine neurons. Perfusion with PCP concentrations from 10 nM to 100 μM resulted in only minimal decreases in firing rate. Neither excitatory effects nor changes in firing pattern were ever observed upon exposure to PCP. In contrast, PCP selectively antagonized the stimulatory effects of N-methyl-D-aspartate (NMDA), but did not alter α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)- or kainate (KA)-induced excitations. These results are discussed in relation to the low-dose stimulatory effects of PCP on ventral tegmental A10 dopamine neurons in the whole animal preparation.",

author = "Ting Wang and French, {Edward D.}",

note = "Funding Information: This work was supported~ np art by USPHS grants DA 03876 and MH 44211",

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T2 - An extracellular in vitro study

AU - Wang, Ting

AU - French, Edward D.

N1 - Funding Information: This work was supported~ np art by USPHS grants DA 03876 and MH 44211

PY - 1993

Y1 - 1993

N2 - Extracellular single-unit recordings in rat midbrain slices were used to assess the effects of phencyclidine (PCP) on the spontaneous and excitatory amino acid-induced firing of ventral tegmental (VTA) dopamine neurons. Perfusion with PCP concentrations from 10 nM to 100 μM resulted in only minimal decreases in firing rate. Neither excitatory effects nor changes in firing pattern were ever observed upon exposure to PCP. In contrast, PCP selectively antagonized the stimulatory effects of N-methyl-D-aspartate (NMDA), but did not alter α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)- or kainate (KA)-induced excitations. These results are discussed in relation to the low-dose stimulatory effects of PCP on ventral tegmental A10 dopamine neurons in the whole animal preparation.

AB - Extracellular single-unit recordings in rat midbrain slices were used to assess the effects of phencyclidine (PCP) on the spontaneous and excitatory amino acid-induced firing of ventral tegmental (VTA) dopamine neurons. Perfusion with PCP concentrations from 10 nM to 100 μM resulted in only minimal decreases in firing rate. Neither excitatory effects nor changes in firing pattern were ever observed upon exposure to PCP. In contrast, PCP selectively antagonized the stimulatory effects of N-methyl-D-aspartate (NMDA), but did not alter α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)- or kainate (KA)-induced excitations. These results are discussed in relation to the low-dose stimulatory effects of PCP on ventral tegmental A10 dopamine neurons in the whole animal preparation.

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Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: An extracellular in vitro study

Abstract

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