Effects of oxygen deprivation on incubated rat soleus muscle

Julie M. Fagan; Marc E. Tischler

doi:10.1016/0024-3205(89)90473-6

Effects of oxygen deprivation on incubated rat soleus muscle

Julie M. Fagan, Marc E. Tischler

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.

Original language	English (US)
Pages (from-to)	677-681
Number of pages	5
Journal	Life Sciences
Volume	44
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(89)90473-6
State	Published - 1989

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(89)90473-6

Cite this

@article{fdef585e4dcb4b2cbff1d15df6898c4e,

title = "Effects of oxygen deprivation on incubated rat soleus muscle",

abstract = "Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.",

author = "Fagan, {Julie M.} and {E. Tischler}, Marc",

note = "Funding Information: Supported by an Established Investigatorship of the Amer. Heart Assoc. to M.E.T., by grant AM-28647 from the Natl. Inst. of Arthritis, Diabetes, and Digestive and Kidney Diseases, and by grant NAG2-384 from NASA.",

year = "1989",

doi = "10.1016/0024-3205(89)90473-6",

language = "English (US)",

volume = "44",

pages = "677--681",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Effects of oxygen deprivation on incubated rat soleus muscle

AU - Fagan, Julie M.

AU - E. Tischler, Marc

N1 - Funding Information: Supported by an Established Investigatorship of the Amer. Heart Assoc. to M.E.T., by grant AM-28647 from the Natl. Inst. of Arthritis, Diabetes, and Digestive and Kidney Diseases, and by grant NAG2-384 from NASA.

PY - 1989

Y1 - 1989

N2 - Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.

AB - Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.

UR - http://www.scopus.com/inward/record.url?scp=0024518952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024518952&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(89)90473-6

DO - 10.1016/0024-3205(89)90473-6

M3 - Article

C2 - 2927239

AN - SCOPUS:0024518952

SN - 0024-3205

VL - 44

SP - 677

EP - 681

JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Effects of oxygen deprivation on incubated rat soleus muscle

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this