Effects of oxidative and nitrosative stress in cytotoxicity

David A. Wink, Katrina M. Miranda, Michael G. Espey

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Nitric oxide is a key bioregulatory agent in a wide variety of biological processes, yet it also can have cytotoxic properties. This dichotomy raises the question of how this potentially toxic species can be involved in so many fundamental physiological processes. This articles discusses how the chemistry of nitric oxide might pertain to its observed biology as it relates to oxidative and nitrosative stress in different mechanisms of cytotoxicity.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalSeminars in Perinatology
Issue number1
StatePublished - 2000

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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