Effects of N-allylnormetazocine (skf 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area

E. D. French

doi:10.1016/0028-3908(86)90241-8

Effects of N-allylnormetazocine (skf 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area

E. D. French

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the a₁₀ region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.

Original language	English (US)
Pages (from-to)	447-450
Number of pages	4
Journal	Neuropharmacology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/0028-3908(86)90241-8
State	Published - Apr 1986
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(86)90241-8

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title = "Effects of N-allylnormetazocine (skf 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area",

abstract = "The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the a10 region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.",

author = "French, {E. D.}",

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N1 - Funding Information: This work was supported by USPHS Grant DA 03876.

PY - 1986/4

Y1 - 1986/4

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AB - The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the a10 region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.

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Effects of N-allylnormetazocine (skf 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area

Abstract

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