Effects of intravenous and aerosolized arachidonic acid on alveolar epithelial permeability in rabbits

J. L. Stevenson, S. F. Quan, M. L. Witten, J. N. Hall, H. R. Roseberry, G. C. McNeill, R. J. Lemen

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    To determine whether arachidonic acid (AA) alters alveolar epithelial permeability, we studied the effect of both continuous intravenous and aerosolized AA on clearance of [99m]Tc-DTPA from lung to blood in rabbits. Although intravenous AA increased prostacylin production and aerosolized AA decreased systemic blood pressure, neither continuous intravenous nor aerosolized AA augmented alveolar epithelial permeability.

    Original languageEnglish (US)
    Pages (from-to)113-116
    Number of pages4
    JournalResearch Communications in Chemical Pathology and Pharmacology
    Volume72
    Issue number1
    StatePublished - 1991

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Toxicology
    • Pharmacology
    • Pharmacology, Toxicology and Pharmaceutics(all)

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