TY - JOUR
T1 - Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves
AU - Zabielski, Romuald
AU - Leśniewska, Violetta
AU - Borlak, Jürgen
AU - Gregory, Peter C.
AU - Kiela, Paweł
AU - Pierzynowski, Stefan G.
AU - Barej, Wiesław
N1 - Funding Information:
This work was supported by Grant No. 5 S31001807 from the State Committee for Scientific Research (Poland), and The Swedish Foundation for International Cooperation in Research and Higher Education (STINT, Dnr 97/560). The technical assistance of Mrs. Sieliło and Mr. Jeremic for the bioanalytical measurements is gratefully acknowledged.
PY - 1998/11/30
Y1 - 1998/11/30
N2 - The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms. Copyright (C) 1998 Elsevier Science B.V.
AB - The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms. Copyright (C) 1998 Elsevier Science B.V.
KW - Atropine
KW - CCK-A receptor antagonist
KW - Cholecystokinin
KW - Migrating myoelectric complex
KW - Periodic pancreatic secretion
UR - https://www.scopus.com/pages/publications/0032583135
UR - https://www.scopus.com/pages/publications/0032583135#tab=citedBy
U2 - 10.1016/S0167-0115(98)00139-6
DO - 10.1016/S0167-0115(98)00139-6
M3 - Article
C2 - 9879754
AN - SCOPUS:0032583135
SN - 0167-0115
VL - 78
SP - 113
EP - 123
JO - Regulatory Peptides
JF - Regulatory Peptides
IS - 1-3
ER -