EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS

T. E. Starzl, K. A. Porter, K. Watanabe, C. W. Putnam

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and trebled cell renewal. Glucagon alone had no effect. In small doses, glucagon did not potentiate the action of insulin and in large doses it may have reduced the insulin benefit. These studies explain the development of the previously mysterious Eck fistula syndrome, provide clues about in-vivo cell growth control by hormones, and suggest new lines of inquiry about the pathogenesis and/or treatment of several human disease processes.

Original languageEnglish (US)
Pages (from-to)821-825
Number of pages5
JournalThe Lancet
Volume307
Issue number7964
DOIs
StatePublished - Apr 17 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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