TY - JOUR
T1 - EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS
AU - Starzl, T. E.
AU - Porter, K. A.
AU - Watanabe, K.
AU - Putnam, C. W.
N1 - Funding Information:
operative care of the animals and to the conduct of the experiments. Anthea Phelps, Bill Russell, and Alec Beasley contributed greatly to the pathological-specimen processing, data collection, and Maha’ The statistical analyses were performed by Mr Jack Thirlwell at the St. Mary’s Hospital and Medical School computer unit. Tim Starzl helped always. The work was supported by research grants ,BIRIS 8118-01 and 7227-01 from the Veterans Administration; by grant
Funding Information:
numbers AM-17260 and AM-07772 from the National Institutes of Health; and by grant numbers RR-00051 and RR-00069 from the General Clinical Research Centers Program of the Division of
PY - 1976/4/17
Y1 - 1976/4/17
N2 - Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and trebled cell renewal. Glucagon alone had no effect. In small doses, glucagon did not potentiate the action of insulin and in large doses it may have reduced the insulin benefit. These studies explain the development of the previously mysterious Eck fistula syndrome, provide clues about in-vivo cell growth control by hormones, and suggest new lines of inquiry about the pathogenesis and/or treatment of several human disease processes.
AB - Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and trebled cell renewal. Glucagon alone had no effect. In small doses, glucagon did not potentiate the action of insulin and in large doses it may have reduced the insulin benefit. These studies explain the development of the previously mysterious Eck fistula syndrome, provide clues about in-vivo cell growth control by hormones, and suggest new lines of inquiry about the pathogenesis and/or treatment of several human disease processes.
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U2 - 10.1016/S0140-6736(76)90477-3
DO - 10.1016/S0140-6736(76)90477-3
M3 - Article
C2 - 56646
AN - SCOPUS:0017228395
SN - 0140-6736
VL - 307
SP - 821
EP - 825
JO - The Lancet
JF - The Lancet
IS - 7964
ER -