Effects of ingested vertebrate-derived factors on insect immune responses

Nazzy Pakpour; Michael A. Riehle; Shirley Luckhart

doi:10.1016/j.cois.2014.07.001

Effects of ingested vertebrate-derived factors on insect immune responses

Nazzy Pakpour, Michael A. Riehle, Shirley Luckhart

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

During the process of blood feeding insect vectors are exposed to an array of vertebrate-derived blood factors ranging from byproducts of blood meal digestion to naturally occurring products in the blood including growth hormones, cytokines and factors derived from blood-borne pathogens themselves. In this review, we examine the ability of these ingested vertebrate blood factors to alter the innate pathogen defenses of insect vectors. The ability of these factors to modify the immune responses of insect vectors offers new intriguing targets for blocking or reducing transmission of human disease-causing pathogens.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Current Opinion in Insect Science
Volume	3
DOIs	https://doi.org/10.1016/j.cois.2014.07.001
State	Published - Sep 2014

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Insect Science

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10.1016/j.cois.2014.07.001

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title = "Effects of ingested vertebrate-derived factors on insect immune responses",

abstract = "During the process of blood feeding insect vectors are exposed to an array of vertebrate-derived blood factors ranging from byproducts of blood meal digestion to naturally occurring products in the blood including growth hormones, cytokines and factors derived from blood-borne pathogens themselves. In this review, we examine the ability of these ingested vertebrate blood factors to alter the innate pathogen defenses of insect vectors. The ability of these factors to modify the immune responses of insect vectors offers new intriguing targets for blocking or reducing transmission of human disease-causing pathogens.",

author = "Nazzy Pakpour and Riehle, {Michael A.} and Shirley Luckhart",

note = "Funding Information: We apologize to all our colleagues whose studies could not be covered because of space limitations. This work was supported by the National Institutes of Health , National Institute of Allergy and Infectious Disease grants AI080799 , AI073745 , and AI078183 . Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

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AU - Riehle, Michael A.

AU - Luckhart, Shirley

N1 - Funding Information: We apologize to all our colleagues whose studies could not be covered because of space limitations. This work was supported by the National Institutes of Health , National Institute of Allergy and Infectious Disease grants AI080799 , AI073745 , and AI078183 . Publisher Copyright: © 2014 Elsevier Inc.

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N2 - During the process of blood feeding insect vectors are exposed to an array of vertebrate-derived blood factors ranging from byproducts of blood meal digestion to naturally occurring products in the blood including growth hormones, cytokines and factors derived from blood-borne pathogens themselves. In this review, we examine the ability of these ingested vertebrate blood factors to alter the innate pathogen defenses of insect vectors. The ability of these factors to modify the immune responses of insect vectors offers new intriguing targets for blocking or reducing transmission of human disease-causing pathogens.

AB - During the process of blood feeding insect vectors are exposed to an array of vertebrate-derived blood factors ranging from byproducts of blood meal digestion to naturally occurring products in the blood including growth hormones, cytokines and factors derived from blood-borne pathogens themselves. In this review, we examine the ability of these ingested vertebrate blood factors to alter the innate pathogen defenses of insect vectors. The ability of these factors to modify the immune responses of insect vectors offers new intriguing targets for blocking or reducing transmission of human disease-causing pathogens.

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DO - 10.1016/j.cois.2014.07.001

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ER -

Effects of ingested vertebrate-derived factors on insect immune responses

Abstract

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