Effects of cyclosporin A on a kidney epithelial cell line (LLC-PK1)

G. M. Becker, A. J. Gandolfi, R. B. Nagle

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK1) in culture. CSA (10-5 M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number2
StatePublished - 1987

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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