Effects of cyclosporin A on a kidney epithelial cell line (LLC-PK1)

G. M. Becker; A. J. Gandolfi; R. B. Nagle

Effects of cyclosporin A on a kidney epithelial cell line (LLC-PK₁)

G. M. Becker, A. J. Gandolfi, R. B. Nagle

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK₁) in culture. CSA (10^-5 M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.

Original language	English (US)
Pages (from-to)	277-280
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	56
Issue number	2
State	Published - 1987

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

Cite this

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abstract = "Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK1) in culture. CSA (10-5 M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.",

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year = "1987",

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AU - Gandolfi, A. J.

AU - Nagle, R. B.

PY - 1987

Y1 - 1987

N2 - Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK1) in culture. CSA (10-5 M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.

AB - Cyclosporin A (CSA), a potent immunosuppressant with the adverse side effect of nephrotoxicity, inhibited cell growth of pig kidney tubule cells (LLC-PK1) in culture. CSA (10-5 M) also induced intense cytoplasmic vacuolation and the formation of dense granules. At the same concentration an analogue of CSA, cyclosporin G, had much less effect. This cell line may prove useful for revealing the mechanism of CSA-nephrotoxicity and testing the nephrotoxic potential of new analogues of cyclosporine.

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IS - 2

ER -

Effects of cyclosporin A on a kidney epithelial cell line (LLC-PK₁)

Abstract

ASJC Scopus subject areas

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