TY - JOUR
T1 - Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography
AU - Michaelsen, Kelly E.
AU - Krishnaswamy, Venkataramanan
AU - Shi, Linxi
AU - Vedantham, Srinivasan
AU - Karellas, Andrew
AU - Pogue, Brian W.
AU - Paulsen, Keith D.
AU - Poplack, Steven P.
N1 - Publisher Copyright:
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT). Image data were analyzed from 27 women who underwent four IRB approved NIRST/DBT exams that included fully and mildly compressed breast acquisitions in two projections - craniocaudal (CC) and mediolateral-oblique (MLO) - and generated four data sets per patient (full and moderate compression in CC and MLO views). Breast density was correlated with HbT (r=0.64, p=0.001), water (r=0.62, p=0.003), and lipid concentrations (r=-0.74, p<0.001), but not oxygen saturation. CC and MLO views were correlated for individual subjects and demonstrated no statistically significant differences in grouped analysis. Comparison of compressed and uncompressed imaging demonstrated a significant decrease in oxygen saturation under compression (58% versus 50%, p=0.04). Mammographic breast density categorization was correlated with measured optically derived properties.
AB - Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT). Image data were analyzed from 27 women who underwent four IRB approved NIRST/DBT exams that included fully and mildly compressed breast acquisitions in two projections - craniocaudal (CC) and mediolateral-oblique (MLO) - and generated four data sets per patient (full and moderate compression in CC and MLO views). Breast density was correlated with HbT (r=0.64, p=0.001), water (r=0.62, p=0.003), and lipid concentrations (r=-0.74, p<0.001), but not oxygen saturation. CC and MLO views were correlated for individual subjects and demonstrated no statistically significant differences in grouped analysis. Comparison of compressed and uncompressed imaging demonstrated a significant decrease in oxygen saturation under compression (58% versus 50%, p=0.04). Mammographic breast density categorization was correlated with measured optically derived properties.
KW - breast tomosynthesis
KW - compression
KW - mammography
KW - near-infrared
UR - http://www.scopus.com/inward/record.url?scp=84990871428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990871428&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.21.9.091316
DO - 10.1117/1.JBO.21.9.091316
M3 - Article
AN - SCOPUS:84990871428
SN - 1083-3668
VL - 21
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 9
M1 - 091316
ER -