Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

J. E. Niederhuber; J. A. Frelinger; E. Dugan; A. Coutinho; D. C. Shreffler

Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

J. E. Niederhuber
, J. A. Frelinger
, E. Dugan
, A. Coutinho
, D. C. Shreffler

Immunobiology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

Original language	English (US)
Pages (from-to)	1672-1676
Number of pages	5
Journal	Journal of Immunology
Volume	115
Issue number	6
State	Published - 1975

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

@article{b0f04b5a9321438fbac6dc936643d0b1,

title = "Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera",

abstract = "Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.",

author = "Niederhuber, \{J. E.\} and Frelinger, \{J. A.\} and E. Dugan and A. Coutinho and Shreffler, \{D. C.\}",

year = "1975",

language = "English (US)",

volume = "115",

pages = "1672--1676",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "6",

}

TY - JOUR

T1 - Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

AU - Niederhuber, J. E.

AU - Frelinger, J. A.

AU - Dugan, E.

AU - Coutinho, A.

AU - Shreffler, D. C.

PY - 1975

Y1 - 1975

N2 - Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

AB - Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

UR - https://www.scopus.com/pages/publications/0016774069

UR - https://www.scopus.com/pages/publications/0016774069#tab=citedBy

M3 - Article

C2 - 1081105

AN - SCOPUS:0016774069

SN - 0022-1767

VL - 115

SP - 1672

EP - 1676

JO - Journal of Immunology

JF - Journal of Immunology

IS - 6

ER -

Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this