Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

J. E. Niederhuber; J. A. Frelinger; E. Dugan; A. Coutinho; D. C. Shreffler

Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

J. E. Niederhuber, J. A. Frelinger, E. Dugan, A. Coutinho, D. C. Shreffler

Immunobiology

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

Original language	English (US)
Pages (from-to)	1672-1676
Number of pages	5
Journal	Journal of Immunology
Volume	115
Issue number	6
State	Published - 1975

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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abstract = "Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.",

author = "Niederhuber, {J. E.} and Frelinger, {J. A.} and E. Dugan and A. Coutinho and Shreffler, {D. C.}",

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AU - Niederhuber, J. E.

AU - Frelinger, J. A.

AU - Dugan, E.

AU - Coutinho, A.

AU - Shreffler, D. C.

PY - 1975

Y1 - 1975

N2 - Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

AB - Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

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Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

Abstract

ASJC Scopus subject areas

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