TY - JOUR
T1 - Effects of anti-Ia sera on mitogenic responses
T2 - II. Differential expression of the Ia marker on phytohemagglutininand concanavalin A-reactive T cells*
AU - Niederhuber, John E.
AU - Frelinger, Jeffrey A.
AU - Dine, Mary S.
AU - Shoffner, Patricia
AU - Dugan, Elizabeth
AU - Shreffler, Donald C.
PY - 1976/2/1
Y1 - 1976/2/1
N2 - Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpepulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.
AB - Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpepulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.
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U2 - 10.1084/jem.143.2.372
DO - 10.1084/jem.143.2.372
M3 - Article
C2 - 1082489
AN - SCOPUS:0017240043
SN - 0022-1007
VL - 143
SP - 372
EP - 381
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -