Abstract
Antiandrogen therapy is an important modality in the treatment of prostate cancer. Recent research into the role of angiogenesis in tumour growth and metastasis has uncovered links between antiandrogen therapy, radiation therapy and angiogenesis, which have exciting implications for the treatment of prostate cancer. Angiogenic cytokines such as vascular endothelial growth factor (VEGF) have been identified in prostate cancer cells and tumours, and androgens appear to stimulate VEGF. This article assesses the antiangiogenic effects of hormonal therapy and assesses the role that angiogenesis may play in the observed cooperation between hormonal and radiation therapies for prostate cancer.
Original language | English (US) |
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Pages (from-to) | 127-132 |
Number of pages | 6 |
Journal | Prostate Cancer and Prostatic Diseases |
Volume | 8 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2005 |
Keywords
- Angiogenesis
- Hormonal therapy
- Prostate cancer
- Radiation therapy
- VEGF
ASJC Scopus subject areas
- Oncology
- Urology
- Cancer Research