Effect of the menstrual cycle on calcium-regulating hormones in the normal young woman

Daniel T. Baran, Michael P. Whyte, Mark R. Haussler, Leonard J. Deftos, Eduardo Slatopolsky, Louis V. Avioli

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


To examine the effect of estrogens on circulating levels of calcium-regulating hormones, total serum calcium, ionized calcium, inorganic phosphate, immunoreactive parathyroid hormone, calcitonin, 1, 25-dihydroxyvitamin D, and estradiol (E2) levels were assayed on menstrual cycle days 3 and 13 in 12 healthy young women. Despite a 3-fold increase in serum E2 levels by midcycle, no differences in the other factors were observed. Furthermore, iv infusion of calcium (3 mg/kg over a 10-min period) produced similar changes in the serum levels of immunoreactive parathyroid hormone and calcitonin on days 3 and 13 in 8 women. Our findings suggest that in normal menstruating women, endogenous increases in E2 neither directly nor indirectly stimulate 1, 25-dihydroxyvitamin D production, nor do they affect circulating levels of the hormones known to influence calcium homeostasis in man.

Original languageEnglish (US)
Pages (from-to)377-379
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Feb 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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