Effect of the ABO blood group on susceptibility to severe malaria: A systematic review and meta-analysis

Abraham Degarege; Merhawi T. Gebrezgi; Gladys Ibanez; Mats Wahlgren; Purnima Madhivanan

doi:10.1016/j.blre.2018.07.002

Effect of the ABO blood group on susceptibility to severe malaria: A systematic review and meta-analysis

Abraham Degarege, Merhawi T. Gebrezgi, Gladys Ibanez, Mats Wahlgren, Purnima Madhivanan

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Understanding how ABO blood group interacts with Plasmodium falciparum (P. falciparum) infection may facilitate development of antimalarial treatments and vaccines. This study systematically summarizes information on the relationship of ABO blood group with severe P. falciparum infection, level of parasitemia and haemoglobin. A total of 1923 articles were retrieved from five databases. After removal of duplicates, and two levels of screening, 21 articles were selected for inclusion in the meta-analysis. A meta-analysis of the studies showed an increased odds of severe P. falciparum infection among individuals with blood group A, B, AB or non-O compared with blood group O. However, the difference in the level of P. falciparum parasitemia was not significant among individuals with blood group A or non-O compared with blood group O. The difference in haemoglobin level among P. falciparum infected individuals was also not significant between those with blood group A, B or AB versus those with blood group O.

Original language	English (US)
Pages (from-to)	53-62
Number of pages	10
Journal	Blood Reviews
Volume	33
DOIs	https://doi.org/10.1016/j.blre.2018.07.002
State	Published - Jan 2019
Externally published	Yes

Keywords

ABO blood group
Haemoglobin
Parasitemia
Severe Plasmodium falciparum

ASJC Scopus subject areas

Hematology
Oncology

Access to Document

10.1016/j.blre.2018.07.002

Cite this

@article{ef0972f839714f75835dd8def574458b,

title = "Effect of the ABO blood group on susceptibility to severe malaria: A systematic review and meta-analysis",

abstract = "Understanding how ABO blood group interacts with Plasmodium falciparum (P. falciparum) infection may facilitate development of antimalarial treatments and vaccines. This study systematically summarizes information on the relationship of ABO blood group with severe P. falciparum infection, level of parasitemia and haemoglobin. A total of 1923 articles were retrieved from five databases. After removal of duplicates, and two levels of screening, 21 articles were selected for inclusion in the meta-analysis. A meta-analysis of the studies showed an increased odds of severe P. falciparum infection among individuals with blood group A, B, AB or non-O compared with blood group O. However, the difference in the level of P. falciparum parasitemia was not significant among individuals with blood group A or non-O compared with blood group O. The difference in haemoglobin level among P. falciparum infected individuals was also not significant between those with blood group A, B or AB versus those with blood group O.",

keywords = "ABO blood group, Haemoglobin, Parasitemia, Severe Plasmodium falciparum",

author = "Abraham Degarege and Gebrezgi, {Merhawi T.} and Gladys Ibanez and Mats Wahlgren and Purnima Madhivanan",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.blre.2018.07.002",

language = "English (US)",

volume = "33",

pages = "53--62",

journal = "Blood Reviews",

issn = "0268-960X",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Effect of the ABO blood group on susceptibility to severe malaria

T2 - A systematic review and meta-analysis

AU - Degarege, Abraham

AU - Gebrezgi, Merhawi T.

AU - Ibanez, Gladys

AU - Wahlgren, Mats

AU - Madhivanan, Purnima

PY - 2019/1

Y1 - 2019/1

N2 - Understanding how ABO blood group interacts with Plasmodium falciparum (P. falciparum) infection may facilitate development of antimalarial treatments and vaccines. This study systematically summarizes information on the relationship of ABO blood group with severe P. falciparum infection, level of parasitemia and haemoglobin. A total of 1923 articles were retrieved from five databases. After removal of duplicates, and two levels of screening, 21 articles were selected for inclusion in the meta-analysis. A meta-analysis of the studies showed an increased odds of severe P. falciparum infection among individuals with blood group A, B, AB or non-O compared with blood group O. However, the difference in the level of P. falciparum parasitemia was not significant among individuals with blood group A or non-O compared with blood group O. The difference in haemoglobin level among P. falciparum infected individuals was also not significant between those with blood group A, B or AB versus those with blood group O.

AB - Understanding how ABO blood group interacts with Plasmodium falciparum (P. falciparum) infection may facilitate development of antimalarial treatments and vaccines. This study systematically summarizes information on the relationship of ABO blood group with severe P. falciparum infection, level of parasitemia and haemoglobin. A total of 1923 articles were retrieved from five databases. After removal of duplicates, and two levels of screening, 21 articles were selected for inclusion in the meta-analysis. A meta-analysis of the studies showed an increased odds of severe P. falciparum infection among individuals with blood group A, B, AB or non-O compared with blood group O. However, the difference in the level of P. falciparum parasitemia was not significant among individuals with blood group A or non-O compared with blood group O. The difference in haemoglobin level among P. falciparum infected individuals was also not significant between those with blood group A, B or AB versus those with blood group O.

KW - ABO blood group

KW - Haemoglobin

KW - Parasitemia

KW - Severe Plasmodium falciparum

UR - http://www.scopus.com/inward/record.url?scp=85049925102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049925102&partnerID=8YFLogxK

U2 - 10.1016/j.blre.2018.07.002

DO - 10.1016/j.blre.2018.07.002

M3 - Review article

C2 - 30029997

AN - SCOPUS:85049925102

SN - 0268-960X

VL - 33

SP - 53

EP - 62

JO - Blood Reviews

JF - Blood Reviews

ER -

Effect of the ABO blood group on susceptibility to severe malaria: A systematic review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this