TY - JOUR
T1 - Effect of stimulus level and frequency on ABR and MLR binaural interaction in human neonates
AU - Cone-Wesson, Barbara
AU - Ma, Ellen
AU - Fowler, Cynthia G.
N1 - Funding Information:
This work was supported by March of Dimes Birth Defects Foundation Grant 12-250 to Barbara Cone-Wesson. The authors wish to acknowledge Shirley Alexander, Alicia Czuzak, Valerie Hewlitt, Katherine Koesbsell, Charlene Mikami, Glendy Ramirez and Patricia Sencer-Padlibsky who assisted in data collection and analysis. The authors also wish to acknowledge Paul Wu, M.D., and Robert deLemos, M.D., of the Neonatology Division at LAC+USC Medical Center. We appreciate the insightful comments of three anonymous reviewers.
PY - 1997/4
Y1 - 1997/4
N2 - Auditory brainstem (ABR) and middle latency (MLR) responses were evoked by click and tone-burst stimuli from human neonates. Electrophysiologic evidence of binaural interaction was measured by subtracting waveforms obtained for binaural stimulus conditions from waveforms obtained for the sum of right ear monaural and left ear monaural stimulus conditions. The effects of stimulus level and stimulus frequency on binaural interaction were evaluated by measuring the number, latency and amplitude of components found in the derived binaural interaction waveform, that is, binaural interaction components (BIC). BICs were more prevalent in the latency range of ABRs than for MLRs. Click and tonal stimuli were equally effective for deriving ABR-BICs, while tone-bursts were somewhat less effective than clicks for deriving MLR-BICs. Stimulus-response dependencies for ABR and MLR component latencies were apparent in monaural, binaural and binaural interaction waveforms. Normalized amplitudes for BICs showed that low-frequency tone-burst stimuli resulted in the largest values compared to click and high-frequency tonal stimuli. Comparison of these results with published results from adults demonstrated immaturity of binaural interaction in neonates.
AB - Auditory brainstem (ABR) and middle latency (MLR) responses were evoked by click and tone-burst stimuli from human neonates. Electrophysiologic evidence of binaural interaction was measured by subtracting waveforms obtained for binaural stimulus conditions from waveforms obtained for the sum of right ear monaural and left ear monaural stimulus conditions. The effects of stimulus level and stimulus frequency on binaural interaction were evaluated by measuring the number, latency and amplitude of components found in the derived binaural interaction waveform, that is, binaural interaction components (BIC). BICs were more prevalent in the latency range of ABRs than for MLRs. Click and tonal stimuli were equally effective for deriving ABR-BICs, while tone-bursts were somewhat less effective than clicks for deriving MLR-BICs. Stimulus-response dependencies for ABR and MLR component latencies were apparent in monaural, binaural and binaural interaction waveforms. Normalized amplitudes for BICs showed that low-frequency tone-burst stimuli resulted in the largest values compared to click and high-frequency tonal stimuli. Comparison of these results with published results from adults demonstrated immaturity of binaural interaction in neonates.
KW - auditory brainstem response
KW - binaural interaction component
KW - middle latency response
KW - neonate
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U2 - 10.1016/S0378-5955(97)00016-6
DO - 10.1016/S0378-5955(97)00016-6
M3 - Article
C2 - 9112116
AN - SCOPUS:0030900642
SN - 0378-5955
VL - 106
SP - 163
EP - 178
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -