Effect of spatial noise of medical grade Liquid Crystal Displays (LCD) on the detection of micro-calcifications

Hans Roehrig, Jiahua Fan, William J. Dallas, Elizabeth A. Krupinski, Jeffrey Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution


This presentation describes work in progress that is the result of an NIH SBIR Phase 1 project that addresses the wide- spread concern for the large number of breast-cancers and cancer victims [1, 2]. The primary goal of the project is to increase the detection rate of microcalcifications as a result of the decrease of spatial noise of the LCDs used to display the mammograms [3, 4]. Noise reduction is to be accomplished with the aid of a high performance CCD camera and subsequent application of local-mean equalization and error diffusion [5, 6]. A second goal of the project is the actual detection of breast cancer. Contrary to the approach to mammography, where the mammograms typically have a pixel matrix of approximately 1900 x 2300 pixels, otherwise known as FFDM or Full-Field Digital Mammograms, we will only use sections of mammograms with a pixel matrix of 256 x 256 pixels. This is because at this time, reduction of spatial noise on an LCD can only be done on relatively small areas like 256 x 256 pixels. In addition, judging the efficacy for detection of breast cancer will be done using two methods: One is a conventional ROC study [7], the other is a vision model developed over several years starting at the Sarnoff Research Center and continuing at the Siemens Corporate Research in Princeton NJ [8].

Original languageEnglish (US)
Title of host publicationPenetrating Radiation Systems and Applications X
StatePublished - 2009
EventPenetrating Radiation Systems and Applications X - San Diego, CA, United States
Duration: Aug 6 2009Aug 6 2009

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherPenetrating Radiation Systems and Applications X
Country/TerritoryUnited States
CitySan Diego, CA


  • Detection of micro-calcification
  • Noise free template pixel
  • Noise reduction by error diffusion
  • Power law as function of lesion size
  • Siemens visual discrimination model
  • Spatial noise
  • Threshold detection of anatomical noise

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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