TY - JOUR
T1 - Effect of sound on gap-junction-based intercellular signaling
T2 - Calcium waves under acoustic irradiation
AU - Deymier, P. A.
AU - Swinteck, N.
AU - Runge, K.
AU - Deymier-Black, A.
AU - Hoying, J. B.
N1 - Publisher Copyright:
© 2015 American Physical Society.
PY - 2015/11/9
Y1 - 2015/11/9
N2 - We present a previously unrecognized effect of sound waves on gap-junction-based intercellular signaling such as in biological tissues composed of endothelial cells. We suggest that sound irradiation may, through temporal and spatial modulation of cell-to-cell conductance, create intercellular calcium waves with unidirectional signal propagation associated with nonconventional topologies. Nonreciprocity in calcium wave propagation induced by sound wave irradiation is demonstrated in the case of a linear and a nonlinear reaction-diffusion model. This demonstration should be applicable to other types of gap-junction-based intercellular signals, and it is thought that it should be of help in interpreting a broad range of biological phenomena associated with the beneficial therapeutic effects of sound irradiation and possibly the harmful effects of sound waves on health.
AB - We present a previously unrecognized effect of sound waves on gap-junction-based intercellular signaling such as in biological tissues composed of endothelial cells. We suggest that sound irradiation may, through temporal and spatial modulation of cell-to-cell conductance, create intercellular calcium waves with unidirectional signal propagation associated with nonconventional topologies. Nonreciprocity in calcium wave propagation induced by sound wave irradiation is demonstrated in the case of a linear and a nonlinear reaction-diffusion model. This demonstration should be applicable to other types of gap-junction-based intercellular signals, and it is thought that it should be of help in interpreting a broad range of biological phenomena associated with the beneficial therapeutic effects of sound irradiation and possibly the harmful effects of sound waves on health.
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U2 - 10.1103/PhysRevE.92.052711
DO - 10.1103/PhysRevE.92.052711
M3 - Article
C2 - 26651727
AN - SCOPUS:84947247262
SN - 1539-3755
VL - 92
JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
IS - 5
M1 - 052711
ER -