Effect of pH on injection phlebitis

Pahala Simamora; Sirirat Pinsuwan; Joan M. Alvarez; Paul B. Myrdal; Samuel H. Yalkowsky

doi:10.1002/jps.2600840427

Effect of pH on injection phlebitis

Pahala Simamora, Sirirat Pinsuwan, Joan M. Alvarez, Paul B. Myrdal, Samuel H. Yalkowsky

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.

Original language	English (US)
Pages (from-to)	520-522
Number of pages	3
Journal	Journal of pharmaceutical sciences
Volume	84
Issue number	4
DOIs	https://doi.org/10.1002/jps.2600840427
State	Published - Apr 1995

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600840427

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title = "Effect of pH on injection phlebitis",

abstract = "Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.",

author = "Pahala Simamora and Sirirat Pinsuwan and Alvarez, {Joan M.} and Myrdal, {Paul B.} and Yalkowsky, {Samuel H.}",

year = "1995",

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AU - Simamora, Pahala

AU - Pinsuwan, Sirirat

AU - Alvarez, Joan M.

AU - Myrdal, Paul B.

AU - Yalkowsky, Samuel H.

PY - 1995/4

Y1 - 1995/4

N2 - Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.

AB - Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.

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Effect of pH on injection phlebitis

Abstract

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