Effect of pH on injection phlebitis

Pahala Simamora, Sirirat Pinsuwan, Joan M. Alvarez, Paul B. Myrdal, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.

Original languageEnglish (US)
Pages (from-to)520-522
Number of pages3
JournalJournal of pharmaceutical sciences
Issue number4
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Pharmaceutical Science


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