Effect of oral contraceptives on plasma clearance

Dean E. Carter, Rubin Bressler, Mark R. Hughes, Mark R. Haussler, C. Donald Christian, M. Wayne Heine

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The effects of chronic steroid contraceptive therapy on drug clearance from plasma were studied by using plasma antipyrine, phenylbutazone, and cholecalciferol half-lives in women. After 3 mo of oral steroid therapy (Norinyl, 2 mg; norethindrone + mestranol), the antipyrine half-life was increased in 3 of 6 subjects, phenylbutazone half-life was not consistently altered, and vitamin D3 half-life was increased in 3 of 4 patients. After 1 to 7 yr of oral steroid therapy, the antipyrine half-life was longer while taking the contraceptive than when the contraceptive treatment was discontinued in 4 of 6 subjects, whereas that of phenylbutazone was not consistently altered.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalClinical Pharmacology and Therapeutics
Issue number6
StatePublished - Dec 1975
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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