Effect of Human Seminal Plasma on the Lytic Activity of Natural Killer Cells and Presumptive Identification of Participant Macromolecules

RICHARD J. ABLIN; JOHN M. BARTKUS; JANOS POLGÁR

doi:10.1111/j.1600-0897.1990.tb00689.x

Effect of Human Seminal Plasma on the Lytic Activity of Natural Killer Cells and Presumptive Identification of Participant Macromolecules

RICHARD J. ABLIN, JOHN M. BARTKUS, JANOS POLGÁR

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

ABSTRACT: Using the lytic activity of natural killer (NK) cells as an in vitro parameter, the immunoregulatory properties of human seminal plasma (SeP1) and participant macromolecules have been investigated. Significant (P < 0.05) suppression of NK cell activity by SeP1 and chromatographically separable fractions was demonstrated in association with high and low molecular weight (M_r) macromolecules. SePl suppression was retained after heating to 56°C for 30 min, and appeared to function at the level of the effector, rather than target cell. Physicochemical characterization of high and low M_r fractions provided presumptive identification of the participation of transglutaminase and prostaglandins as the principal molecules contributory to SeP1 immunosuppression. 1990 Munksgaard

Original language	English (US)
Pages (from-to)	15-21
Number of pages	7
Journal	American Journal of Reproductive Immunology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0897.1990.tb00689.x
State	Published - Sep 1990
Externally published	Yes

Keywords

Immunoregulatory properties
immunosuppression
prostaglandins
seminal plasma
transglutaminase

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1111/j.1600-0897.1990.tb00689.x

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AU - POLGÁR, JANOS

PY - 1990/9

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AB - ABSTRACT: Using the lytic activity of natural killer (NK) cells as an in vitro parameter, the immunoregulatory properties of human seminal plasma (SeP1) and participant macromolecules have been investigated. Significant (P < 0.05) suppression of NK cell activity by SeP1 and chromatographically separable fractions was demonstrated in association with high and low molecular weight (Mr) macromolecules. SePl suppression was retained after heating to 56°C for 30 min, and appeared to function at the level of the effector, rather than target cell. Physicochemical characterization of high and low Mr fractions provided presumptive identification of the participation of transglutaminase and prostaglandins as the principal molecules contributory to SeP1 immunosuppression. 1990 Munksgaard

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Effect of Human Seminal Plasma on the Lytic Activity of Natural Killer Cells and Presumptive Identification of Participant Macromolecules

Abstract

Keywords

ASJC Scopus subject areas

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